Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function.
نویسندگان
چکیده
منابع مشابه
Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function.
This study examined effects of nonpeptide angiotensin II (Ang II) receptor subtype antagonists on the interaction of sympathetic function and Ang II in pithed rats. Effects of spinal cord stimulation (0.5-4 Hz) and norepinephrine (0.3-3 micrograms/kg i.v.) on mean arterial pressure (recorded with a carotid arterial catheter), cardiac output (measured with an electromagnetic flowmeter and flow p...
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Blood pressure reduction is the most significant factor in delaying onset and progression of renal disease. Blockade of the renin-angiotensin system (RAS) using angiotensin-converting enzyme inhibitors (ACEIs) delays renal disease progression. More recently, agents that block the RAS by preventing angiotensin II from binding to its subtype 1 receptor (ARBs) have been developed in an effort to p...
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A clonal rat sympathetic nerve cell line, PC12, binds iodinated cY-bungarotoxin. The binding is saturable and is inhibited by a variety of cholinergic agonists and antagonists. The pseudo-first order rate constant for binding is 2.1 x lo” Mm1 s-l at 22”. In contrast to the cu-bungarotoxin binding reaction found with muscle, the binding to PC12 is reversible with a first order rate constant of 4...
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A clonal rat sympathetic nerve cell line, PC12, binds iodinated alpha-bungarotoxin. The binding is saturable and is inhibited by a variety of cholinergic agonists and antagonists. The pseudo-first order rate constant for binding is 2.1 x 10(5) M-1 S-1 at 22 degrees. In contrast to the alpha-bungarotoxin binding reaction found with muscle, the binding to PC12 is reversible with a first order rat...
متن کاملRapid Communication Distribution of Type 1 Angiotensin II Receptor Subtype Messenger RNAs in the Rat Fetus
The localization of the two type 1 angiotensin II receptor subtype (AT1A and AT1B) messenger RNAs in the 19-day-old rat fetus was studied by in situ hybridization. AT! receptor mRNAs were detected in target organs of the reninangiotensin system such as the kidney, adrenal gland, liver, heart, large arteries, and pituitary gland. In addition, angiotensin II receptors were present in specialized ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1992
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.19.6.663